3 - Bromo - 4 - methylacetophenone from

Bromo-4-methylacetophenone from aluminum chloride catalyzed bromination of 4-methylacetophe-none, 40, 9... 

From the diverse examples on Hantzsch syntheses reported, the reaction of 2-bromo-4 -methylacetophenone and l-acetyl-2-thiourea was exemplarily chosen to be represented here [10]. 

It is interesting to point out that the combination of cyclopropane and cyclobutane chemistry has allowed the synthesis of all three regioisomers of cuparenone possessing a cyclopentanone bearing two quartemary centers in the vicinal position from p-methylacetophenone and a-selenoalkyllithiums (Scheme 98). It can be noted than a-Lithiocyclopropyl sulfides or a-lithiocyclopropyl selenides are particularly suitable when a nonalkylated cyclopropane ring is needed whereas a-lithio-a-bromo cyclopropanes are the reagents of choice for the introduction of the... 

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