2-bromo-6-methoxybenzene-, lithium

However, neither copper(I) iodide nor photostimulation are absolutely necessary for the arylation of benzenetellurolate. Lithium benzenetellurolate and 1,2-bromoiodobenzene condensed in tetrahydrofuran at 20° to form 1,2-bis[phenyltelluro]benzene in 32% yield3. Sodium benzenetellurolate condensed similarly with l-chloro-2,4-dinitrobenzene at 20° in tetrahydrofuran/aqueous sodium hydroxide in the presence of a phase-transfer reagent. In this case 2,4-dinitrophenyl phenyl tellurium (m.p. 134°) was isolated in 30% yield4. Lithium methanetellurolate was arylated in tetrahydrofuran by iodobenzene5, 1,2-dibromobenzene, and l-bromo-2-methoxybenzene at 20°3. 

Reactions of methoxybenzenes or those bearing a fluoro substituent with lithium, an alkyllithium. or a bromo substituent with a Grignard reagent. 

Another q>pToach to the aoidone skeleton, developed by Watanabe et al. 314), was based on an earlio- obsravation that small amounts of aoidones woe formed when benzynes were generated by diazotization of anthranilic acids 315-317). The acridones result in these cases from the reaction of benzynes with undiazotized anthranilic acids. Therefore, a new route was developed through tandem metallation synthesis. The lithium salt of methyl iV-methylanthranilate (250) could be easily coupled with the benzynes 251, 252, and 253, generated by treatment of chlorobenzene, 1 -bromo-2-methoxybenzene, and l-chloro-3,5-... 

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See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ , , ]

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