Bromo domain containing proteins

B. Bromo Domain-Containing Proteins Function in Modifiers... 

New evidence indicates that the major mediators in remodeler recruitment may be bromo and chromo domain-containing proteins. Bromo domains mediate protein binding to acetyl-lysines in histones and other proteins (Jacobson et al., 2000), and chromo domains have been shown to bind methyl-lysines (Jacobs et al., 2002). For instance, TAF1, a component of TFIID, contains two tandem bromo domains that bind selectively to multiply acetylated H4 peptides (Jacobson et al., 2000). Furthermore, the Gcn5 bromo domain preferentially binds acetylated H4 K16 (Owen et al., 2000). 

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