5-Bromo-2-chloro-3-methoxypyrazine

Chloro-3-morpholinopyrazine treated with allyl alcohol followed by bromination in the presence of water has been shown to give 5-bromo-2-(3 -bromo-2-hydroxypropoxy)-3-morpholinopyrazine (813), and bromination of 2-amino[or 2-(p-toluenesulfonamido)]-3-methoxypyrazine with a mixture of potassium bromide and bromate in 6N sulfuric acid gave 2-amino-[or 2-(p-toluenesulfonamido)]-5-bromo-3-methoxypyrazine (814). The bromination (814) of 2-methoxy-3-sulfanilamidopyrazine in methanol was anomalous (815,816) [see Section 5D(2)]. 

---