8- Bromo-cGMP

Tegeder, I., Schmidtko, A., Niederberger, E., Ruth, P., and Geisslinger, G. (2002). Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci. Lett. 332, 146—150. 

The synthesis of two novel caged compounds, 4,5-dimethoxy-2-nitrobenzyl 8-bromo-cAMP (caged 8-Br-cAMP) (76) and 4,5-dimethoxy-2-nitrobenzyl 8-bromo-cGMP (caged 8-Br-cGMP) (77) by reaction of the respective cyclic... 

Bolus injections of SNAP also elicited a dose-dependent decrease in hindquarters perfusion pressure. However, in contrast to the cases of acetylcholine and bradykinin, vasodilator responses to bolus injections of SNAP were not affected during SNAP-phenylephrine infusion. Again, no systemic effects were observed at the doses used. When bolus injections of 8-bromo-cGMP were administered in place of SNAP, identical decreases in hindquarters perfusion pressure were observed in the presence or absence of SNAP-phenylephrine infusion. 

Rashatwar, S. S., Cornwell, T. L., and Lincoln, T. M. (1987). Effects of 8-bromo-cGMP on Ca levels in vascular smooth muscle cells Possible regulation of Ca -ATPase by cGMP-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A. 84, 5685-5689. 

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