Bromo Bromobutyric acid

ETHYL y-BROMOBUTYRATE (Butyric acid, Y-bromo-, ethyl ester)... 

Ethyl 4-bromobutyrate Butyric acid, 4-bromo-, ethyl ester (8) Butanoic acid, 4-bromo-, ethyl ester (9) (2969-81-5)... 

Methyl 2-bromobutyrate Butyric acid (70.4 g) is added to technical SOCl2 (112 g) during 75 min, with stirring, at room temperature, then the mixture is heated on a boiling water-bath for 30 min, after which the SOCl2 excess is distilled off. Bromine (135 g) is added to the residue at 80-90°, with stirring, and the whole is heated for 5 h on a boiling water-bath, then cooled. Methanol (46 ml) is added, and the solution is heated under reflux for 2 h. A small upper layer is formed and is separated in a separatory funnel and discarded. The remainder is distilled in a vacuum after a small forerun has been removed at 100° under atmospheric, pressure. The bromo ester (75-86%) has b.p. 70-75°/15 mm. 

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