2-bromo- acetophenone, asymmetric

Recently, Yadav and colleagues developed a catalytic aziridination reaction of imines via ammonium yUdes and disclosed an example of asymmetric transformation using O-methyl quinine as a catalyst. Under similar reaction conditions (Na2C03, MeCN, 80 °C, 18 h) to Gaunt s, 20mol% catalyst promoted the reaction of N-tosyl benzaldimine with a-bromo acetophenone with high stereoselectivity (78% yield, 92% ee) in favor of the trans product (Scheme 20.31). However, only one example was presented. The generality of this reaction needs to be explored further [57]. 

Asymmetric reduction of 2-bromo-(3-nitro-4-benzyloxy) acetophenone. . 157... 

ASYMMETRIC REDUCTION OF 2-BROMO-(3-NITRO-4-BENZYLOXY)ACETOPHENONE[161... 

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