Brodifacoum metabolism

Leek, J.B., Park, B.K. (1981). A comparative study of the effects of warfarin and brodifacoum on the relationship between vitamin K1 metabolism and clotting factor activity in warfarin-susceptible and warfarin-resistant rats. Biochem. Pharmacol. 30 123-8. 

Weitzel, J.N., Sadowski, J.A., Furie, B.C., Moroose, R., Kim, H., Mount, M.E., Murphy, M.J., Furie, B. (1990). Surreptitious ingestion of a long-acting vitamin K antagonist/rodenticide, brodifacoum clinical and metabolic studies of three cases. Blood 76(12) 2555-9. 

Brodifacoum is an anticoagulant rodenti-cide. The greatest concentration is likely in the liver, where metabolism takes place, because ingestion likely occurred more than 24 hours prior to the onset of signs. Metabolites are more water-soluble and may also be found in the renal tissue. 

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