Briggs, George

George E. Briggs and John B.S. Haldane re-evaluated the Michaelis-Menten equation and contributed to the modem view on the steady-state treatment of enzyme-catalyzed reactions [90]. 

To simplify matters, George Briggs and John Haldane suggested the steady-state assumption in 1924. In a steady state, the concentrations of intermediates-—in this case, [ES]—stay the same even if the concentrations of starting... 

George E. Briggs and John B. S. Haldane, in 1925, examined the earlier Michaeiis-Menten analysis and made an important development. Instead of assuming that the first stage of the reaction was at equilibrium, they merely assumed that, for all intents and purposes, the concentration of the enzyme-substrate complex scarcely changed with time i.e., it is in a steady state. Written mathematically, this amounts to... 

The term pre-equilibrium can also be used in this case. While Michaelis and Menten assumed that the subsequent reaction creating the product runs so slowly as to be negligible, the extended approach of George Edward Briggs and John Burdon Sanderson Haldane (1925) also takes the rate coefficient of the consecutive reaction into account. 

My doubts about Briggs project evaporated as soon as I heard George... 

The author is indebted to loop Blitz, Mike Briggs, Alan Duff, Marc Elenbaas, Dave Hill, Giorgio Locatelli, Franco Moretti, George New, Dave Roberts and notably to John Davidson, who in one way or another, either through their support, discussions or valuable comments helped to create this book. 

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