Bridging methodology

Bridging methodology between different scale levels... 

Also, many of the stnictural and spectroscopic techniques are now being applied to new types of systems, such as those involving the physical adsorption of vapors. Such bridging of methodologies will surely help to keep surface chemistry a single, broad field with good intercommunication between the various subareas. 

Terminal alkylidene complexes generated in this manner can react further with the organometallic substrate when steric interactions are not unfavorable, forming dinuclear species. Herrmann has used this methodology extensively in the preparation of bridging alkylidene complexes (84). 

Additionally, ER groups can also be bonded in bridging configurations in multimetallic compounds (Table 9). These complexes are most often encountered via substitution reactions. Reactions employing the substitution methodology will be discussed in Section 3.08.7. 

The methodology is useful for a variety of synthetic purposes. The cycloadditions are not subject to steric hindrance. Thus diyne cycloadditions to 2,5-disubstituted furans or pyrroles, followed by elimination of the oxygen or nitrogen bridges, provides an excellent, short route to peri-substituted arenes, as in the following examples 4 6 8... 

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