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Bridging biological space

Fig. 23 Bridging biological space. The overlap of epothilone B (cyan carbons) and PTX (green carbons) models derived from EC reveal shared anchors between the exchangeable nucleotide site through H227 and the truncated B9-B10 loop of the beta tubulin site. Perhaps rigidifying this vector across the site is of greater importance to the MT stabilizing effect than picking up interactions within the deep hydrophobic pocket... Fig. 23 Bridging biological space. The overlap of epothilone B (cyan carbons) and PTX (green carbons) models derived from EC reveal shared anchors between the exchangeable nucleotide site through H227 and the truncated B9-B10 loop of the beta tubulin site. Perhaps rigidifying this vector across the site is of greater importance to the MT stabilizing effect than picking up interactions within the deep hydrophobic pocket...
Nettles, J.H., Jenkins, J.L., Bender, A., Deng, Z., Davies, J.W. and Click, M. (2006) Bridging chemical and biological space Target Pishing using 2D and 3D molecular descriptors. Journal of Medicinal Chemistry, 49 (23), 6802-6810. [Pg.320]

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Biological space

Biology space

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