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Brevetoxins toxicology

The toxicological consequences of P. brevis red tides are mass mortality of fishes exposed to the red tide toxic shellfish which, if consumed, result in human neurotoxic shellfish poisoning and an irritating aerosol which results from contact with P. brevis cell particles entrapped in seaspray. In all cases, the threshhold levels for intoxication are in the picomolar to nanomolar concentration ranges, implying a specific locus or loci of action for brevetoxins (reviewed in 6). [Pg.166]

Benson, J.M., Tischler, D.L., and Baden, D.G. 1999. Uptake, tissue distribution, and excretion of brevetoxin 3 administered to rats by intratracheal instillation. Jowrna/ of Toxicology and Environmental Health-Part A 57, 345-355. [Pg.44]

Rodgers, R.L., Chou, H.N., Temma, K., Akera, T, and Shimizu, Y. 1984. Positive inotropic and toxic effects of brevetoxin-B on rat and guinea-pig heart. Toxicology and Applied Pharmacology 76, 296-305. [Pg.47]

Ishida, H., Nozawa, A., Nukaya, H., Rhodes, L., McNabb, P., Holland, P.T., and Tsuji, K. Brevetoxin metabolism in shellfish associated with neurotoxic shellfish poisoning, in Mycotoxins and Phycotoxins Advances in determination, toxicology and exposure management, Njapau, H., Trujillo, S., van Egmond, H.P., Park, D.L. Eds., Wageningen Academic Publishers, The Netherlands, 2006, pp. 297-307. [Pg.468]

Taken together, toxicological studies with brevetoxins indicate that the intrinsic potency of bre-vetoxin (PbTx-3) is approximately 5 ng/g and accountable largely by afhnity for binding to the volt-age-gated sodium channel. Integrated toxicity by bath application to hsh or interperitoneal injection to mice yields a reduction in potency of 3- and 40-fold, respectively, likely reflective of differences in uptake and disposition of the toxin. Specialized exposures indicate that PbTx-2 is several-fold less potent orally than interperitoneal in mice and highly potent for localized action on airway constriction by aerosolized exposure to sheep but not for systemic effects in mice or rats. [Pg.526]


See other pages where Brevetoxins toxicology is mentioned: [Pg.193]    [Pg.50]    [Pg.56]    [Pg.20]    [Pg.22]    [Pg.24]    [Pg.26]    [Pg.30]    [Pg.32]    [Pg.34]    [Pg.36]    [Pg.38]    [Pg.40]    [Pg.42]    [Pg.44]    [Pg.46]    [Pg.49]    [Pg.448]    [Pg.520]    [Pg.524]    [Pg.264]   
See also in sourсe #XX -- [ Pg.471 ]




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Brevetoxin

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