Thromboplastin brain

Thrombin is prepared from bovine plasma by reacting thrombin with thromboplastin in the presence of calcium. Thromboplastin is prepared as a micellar suspension of at least six phosphohpids extracted from porcine brain and mixed in fixed proportions. It is stable at +4 C for several years (19). 

Thromboplastin III Not applicable, (Exogenous material containing both tissue factor and phospholipids) NA NA Homogenate of brain or lung in physiological NaCUiCaCy NA NA... 

Thromboplastin is present in tissue juices and in platelets. In experimental studies on blood coagulation, thromboplastin is usually obtained by extracting it with saline from brain or lung. In the blood vessels, the thromboplastin that starts the coagulation process is generated by the disintegration of the blood platelets (which will be discussed in more detail later), but thromboplastin release coincides with the release of vasconstricting substances. 

PE, PS, lecithin Beef and pork brain, synthetic, egg Folch fractionation, purification, silicic acid chromatography Hicks-Pitney, (1957) TGT, recalcification time, anti-thromboplastin test, Stypven PS—anticoagulant effect when solubilized in albumin or desoxycholate PE active in Hicks-Pitney and Stypven synthetic PE active in Hicks-Pitney lecithin inert Silver et al. (1963)... 

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