Bradykinin biological effects

Incubation of a protein fraction from blood plasma with trypsin gives rise to peptides with conspicuous biological effects. Pain, dilation of peripheral blood vessels, increased coronary flow and enhanced capillary permeability were observed on administration of these protein fragments [8]. In the early sixties the nonapeptide bradykinin and its precursors, kallidin and methionyl-kalUdin were isolated in pure form and their amino acid sequences determined soon after. 

Albumin solutions are manufactured from pooled plasma. They can contain other plasma constituents, such as heme compounds, prekalli-krein, endotoxins, bradykinin and bilirubin, in sufficient concentrations to cause clinical effects (Pulimood Park 2000). Some batches of human albumin have been shown to induce the expression of adhesion molecules on endothelial cells in vitro (Nohe et al 1999), which could result in activation of the immune system in vivo. Despite appropriate precautions during the manufacturing process, there is always a theoretical chance of transmission of disease with any biological product. 

Glycine-8-phenyllactic acid bradykinin (VII) has been synthesized and its biological activity studied. The vaso-depressive effects in the rat and rabbit and the effects on... 

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