Bovine endothelin

Roos, M., Soskic, V., Poznanovic, S., and Godovac-Zimmermaim, J. (1998). Post-translational modifications of endothelin receptor B from bovine lungs analyzed by mass spectrometry. J. Biol. Chem. 273, 924-931. 

Therefore, arteriosclerosis arteries are more prone to vasospastic events than are normal blood vessels [98]. One feature of this disease is the impairment of the relaxations mediated by the endothelium. This endothelial abnormality appears to be partially due to a defect of the metabolism of EDRF by Ox-LDL which accumulates within human atherosclerotic plaques. However, an enhanced production of the potent vasoconstrictor peptide endothelin could also participate in vasospasm. It has been reported that Ox-LDL induces the release of endothelin from human and porcine endothelium [126,127] and from bovine endothelium [128]. 

Okada, K., Arai, Y., Hata, M., Matsuyama, K., and Yano, M. (1993) Big endothelin-1 structure important for specific processing by endothelin-converting enzyme of bovine endothelial cells. Eur. J. Biochem. 218, 493-498. 

Cell fractionation studies in bovine carotid artery first demonstrated that phorbol esters, histamine, angiotensin, and endothelin, but not KCl, induced a translocation of PKC from the cytosol to the membrane fraction (Haller et al., 1990), although the identity of the membranes involved was not determined (Table I). Work with the non-isoform-specific fluorescent PKC probe Bodipy phorbol (Khalil and Morgan,... 

Malek, A. M., and Izumo, S. (1992). Physiological fluid shear stress causes down regulation of endothelin 1 mRNA in bovine aortic endothelium. Am. J. Physiol. 263, C389-C396. 

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