Botulinum neurotoxins characteristics

Ashton, A. C., de Paiva, A. M., Poulain, B., Tauc, L. and Dolly, J. 0., 1993, Factors underlying the characteristic inhibition of the neuronal release of transmitters by tetanus and various botulinum neurotoxins. In Botulinum and Tetanus Neurotoxins Neurotransmission and Biomedical Aspects (B. R. DasGupta, ed.), Plenum Press, New York. pp. 191-213. 

Simpson LL (2000) Identification of the characteristics that underlie botulinum toxin potency implications for designing novel drugs. Biochimie 82 943-53 Simpson LL, Lautenslager GT, Kaiser II, Middlebrook JL (1993) Identification of the site at which phospholipase A2 neurotoxins localize to produce their neuromuscular blocking effects. Toxicon 31 13-26... 

A. Characteristics. Botulism is caused by intoxication with any of the seven distinct neurotoxins produced by the bacillus Clostridium botulinum. The toxins are proteins that bind to the presynaptic membrane of neurons at peripheral cholinergic synapses to prevent release of acetylcholine and block neurotransmi ssion. 

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