Boronic acid bioisostere

Chart 8 Chemical structures of the CA4 boronic acid bioisostere (9) and of MDL-27048. The former was proposed by a structure-based molecular modeling study, the latter was used to elaborate a virtual screening protocol for the identification of novel chalcone CSI... 

Recently a boronic acid residue was used to mimic the 3 -OH in Combretastatin A-4 the biological data demonstrated that the cis boronic acid analogue is a viable bioisostere of Combretastatin A-4 [18]. 

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