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Boranes by hydroboration

Scheme 23. Synthesis of vinyl boranes by hydroboration of alkynes. Scheme 23. Synthesis of vinyl boranes by hydroboration of alkynes.
The trialkylborane is derived from monoalkyl-(l,l,2-trimethylpropyl)borane by hydroboration. Care must be taken in the oxidation step leading to the a-chiral ketones and buffering is necessary to avoid racemization. However, even with these precautions, 2-6% racemization is observed in some cases9,20. The intermediate alkenyl-(l,l,2-trimethylpropyl)borinates are relatively resistant to oxidation thus prolonged reaction times or higher temperatures are sometimes required to complete the reaction via the haloalkyne route. [Pg.281]

Scheme 3.59 Synthesis of fluoroalkylated alkenyl boranes by hydroboration. Scheme 3.59 Synthesis of fluoroalkylated alkenyl boranes by hydroboration.
Synthesis of Aminoalkyl Boranes by Hydroboration and their Suzuki Cross-coupling Reaction... [Pg.91]

See also in sourсe #XX -- [ Pg.226 , Pg.227 , Pg.228 , Pg.229 , Pg.230 , Pg.231 ]

See also in sourсe #XX -- [ Pg.226 , Pg.227 , Pg.228 , Pg.229 , Pg.230 , Pg.231 ]



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Boranes hydroboration

Hydroboration borane

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