Bone pathology

The early stages of bone pathology in rheumatoid disease manifest as periarticular osteoporosis and juxta-articular bone erosion. Osteoclast overactivity is the predominant influence in such bone erosion and NO has a direct inhibitory efiect on osteoclastic bone resorption (MacIntyre et al., 1991). Endothelial cells, present in abundance and in close proximity to the osteoclast may therefore play a role in down-regulating osteoclast activity through the production of NO. Since the osteoclast is of macrophage lineage, it is likely to be... 

R. Cubeddu, Optical biopsy of bone tissue A step toward the diagnosis of bone pathologies. J. Biomed. Opt. 9, 474-480 (2004)... 

Stacker Frankly, no. We have done the VEGF-D knockout and we don t see any bone pathologies. 

Yazici M, SOzubir S, Kilicoglu G (1998) Three-dimensional anatomy of the pelvis in bladder exstrophy description of bone pathology by using three-dimensional computed tomography and its clinical relevance. J Pediatr Orthop 18 132-135... 

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