Blue copper proteins identification

Rusticyanin is an abundant, highly stable periplasmic blue copper protein (e.g., Cobley and Haddock 1975 Jedlicki et al. 1986 Ronk et al. 1991 Nunzi et al. 1993 Blake et al. 1993). Studies of rusticyanin include kinetic competence in the iron oxidation reaction (Blake and Shute 1994), identification of a His ligand to the copper center (Casimiro et al. 1995), a solution NMR structure (Botuyan et al. 1996), and a high-resolution X-ray structure (Walter et al. 1996). Rusticyanin forms a complex with new c-type heme cytochrome in iht A. ferrooxidans electron transport chain (Giudici-Orticoni et al. 2000). 

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