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Blood vessels, adenylyl cyclases

The effects of VIP are mediated by G protein-coupled receptors two subtypes, VPAC1 and VPAC2, have been cloned from human tissues. Both subtypes are widely distributed in the central nervous system and in the heart, blood vessels, and other tissues. VIP has a high affinity for both receptor subtypes. Binding of VIP to its receptors results in activation of adenylyl cyclase and formation of cAMP, which is responsible for the vasodilation and many other effects of the peptide. Other actions may be mediated by inositol trisphosphate synthesis and calcium mobilization. [Pg.387]

See other pages where Blood vessels, adenylyl cyclases is mentioned: [Pg.607]    [Pg.363]    [Pg.466]    [Pg.466]    [Pg.99]    [Pg.112]    [Pg.177]    [Pg.183]    [Pg.23]   
See also in sourсe #XX -- [ Pg.363 ]



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Adenylyl cyclase

Adenylyl-

Adenylylation

Blood vessels

Cyclase

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