Blood disorders coagulation

Apart from blood coagulation disorders, the main complication of streptokinase, this enzyme can produce reactions suggestive of aUeigic manifestations such as fever, hypotension and flushing (2 ), as well as rashes and arthralgia (9 ). Attainment of a high plasma titre of streptococcal antibodies during the infusion renders further treatment impossible for at least 6 months ( ). 

The hemorrhagic diathesis in patients with coagulation disorders is because of either an abnormaUty of one or more plasma proteins and/or platelets necessary for normal blood coagulation or the spontaneous presence of a circulating anticoagulant. Specific laboratory techniques are required for the precise identification of these disorders. 

Machovich R (2003) Disorders of the blood coagulation-fibrinolytic system. In Keri Gy, Toth I (eds) Molecular pathomechanism and new bends in drug research. Taylor and Francis Group, London and New York, pp 458-464... 

Recessively inherited coagulation disorders (RICDs) refer to relatively rare deficiencies in factor II, V, VII, and X-XIII resulting in either decreased clotting factor production or production of a dysfunctional molecule with reduced activity.19 The clinical severity of bleeding varies and generally is poorly correlated with the factor blood levels. Table 64-6 illustrates these clotting factor deficiencies and some of their characteristics. 

The main goal of recessively inherited coagulation disorder (RICD) treatment is to prevent and control spontaneous and surgery-related bleeding episodes. Specifically, therapeutic options improve hemostasis via replacement of deficient blood coagulation factors while minimizing the development of immune tolerance.20... 

Table 12.2 Recombinant blood coagulation factors that have been approved for the management of coagulation disorders...

Cirrhosis results in elevation of portal blood pressure because of fibrotic changes within the hepatic sinusoids, changes in the levels of vasodilatory and vasoconstrictor mediators, and an increase in blood flow to the splanchnic vasculature. The pathophysiologic abnormalities that cause it result in the commonly encountered problems of ascites, portal hypertension and esophageal varices, HE, and coagulation disorders. 

Blood coagulation factors Haemophilia and other related blood disorders Human blood... 

Blood Modifier/Vitamin K] Uses Coagulation disorders d/t faulty... 

I 14 Kane WH, Davie EW. Blood coagulation factors V and VIII structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders. Blood 1988 71 539-555. 

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