Nonapeptides, blocked

For the combination of segments according to this 3 + 4 = 7 2 + 7 = 9 scheme, the tetraethyl pyrophosphite method, which had just been developed, (G.W. Anderson et al.) [21] was applied. The blocked nonapeptide was secured in low... 

Synthesis of oxytocin was soon attempted in several laboratories. In 1955, Boissonnas and his group [25] in Basel, Switzerland, and in 1956, Rudinger and his associates [26] in Prague, Czechoslovakia, reported overall yields of about 5%. This was substantially higher than the yield achieved in New York. In both instances mixed anhydrides were used for the preparation of segments and the classical azide procedure of Curtius [27] (p. 26) for their combination into the molecule of the hormone. Further improvement both in yield (about 10%) and in the quality of the blocked nonapeptide intermediate was reported in a modified... 

ALX40 nonapeptide of D-arginine Blocks CXCR4 Blocks SDF-1-induced calcium flux and T-tropic HIV infection in vitro... 

An attractive possibility in the selection of blocking groups is to provide for simultaneous deprotection at the conclusion of the chain building procedure. For instance the final nonapeptide derivative in the first synthesis of the hormone oxytocin (du Vigneaud et al. 1953)... 

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