Blind tests success rates

The efficacy, safety, and tolerability of voriconazole and fluconazole have been compared in 391 immunocompromised adults with esophageal candidiasis in a randomized, double-blind, multicenter trial (11). Most of the patients (94%) had AIDS. Following randomization, they took either voriconazole (200 mg bd) or fluconazole (400 mg on day 1 followed by 200 mg od) for a median of 14 or 15 days respectively. Treatment was continued for 7 days after the resolution of aU signs and symptoms but was not allowed to exceed 42 days. The two drugs achieved comparable success rates (98% voriconazole, 95% fluconazole), as assessed by esophagoscopy in the primary efficacy analysis in 256 patients. More patients discontinued voriconazole because of laboratory test abnormalities (3.5 versus 1%) or treatment-related adverse events (2.5 versus 0.5%). The most frequent... 

Fig. 4 The molecules used in the blind tests of crystal structure prediction, organized by the Cambridge Crystallographic Data Centre in 1999 and 2001. For each molecule, the success rate is given as x/y, where x is the number of successful predictions, and is the number of groups that submitted (usually) three guesses for the crystal Structure.

Table 2.2 Success rates in the blind tests of crystal structure prediction ...

The publication of the first blind test does not report enough detail to know the overall success rate of the search methods. 

Principal components analysis followed by linear discriminant analysis of the NMR spectra from 98 instant spray dried coffees, obtained from 3 different producers, correctly attributed 99% of the samples to their manufacturer. Blind testing of the PCA model with a further 36 samples of instant coffee resulted in a 100% success rate in identifying the samples from the 3 manufacturers. Coffees from one manufacturer were also assigned into 2 groups using these techniques... 

Table 1 Rates of success in the first four blind tests of crystal structure prediction. Molecule numbers refer to the numbering used in the blind test publications and Figure 6.

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