Bleomycins indium-111 complexes

The role of metal speciation in bleomycin uptake and cytotoxicity has been studied extensively. The relatively high amounts of copper in the blood, however,suggest that exogenous or endogenous metals in the blood do not markedly alter the uptake or activity of bleomycin. Nonetheless, a number of other metals can bind to bleomycin including indium and cobalt, and formulating bleomycin with these ex vivo can significantly reduce the cytotoxicity of bleomycin (Lyman et al. 1986). Complexes of this type have been used, however, to examine tumor cell uptake of bleomycin compounds. 

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