Bleomycin manganese

Burger RM, Kent TA, Horwitz SB, Munck E, Peisach J (1983) Mossbauer study of iron bleomycin and its activation intermediates. J Biol Chem 258 1559-1564 Burger RM, Freedman JH, Horwitz SB, Peisach J (1984) DNA degradation by manganese(l)-bleomy-cin plus peroxide. Inorg Chem 23 2215-2217... 

Additionally, the mechanistic similarities between bleomycin and cytochrome P450 45,159-162) led to the test of manganese bleomycin for DNA strand scission 163,164). 

In summary, manganese bleomycin is able to mediate DNA degradation in the presence of ascorbate (but not with 2-mercaptoethanol for an unknown reason) or iodosylbenzene. It is less efficient than its iron bleomycin congener. The detailed mechanism of the DNA damage by manganese bleomycin as well as the reason for its lower efficiency were not investigated. 

The catalytic antioxidant porphyrin manganese (III) tetrakis (4-benzoic acid) porphyrin (5mg/kg i.p. twice daily) attenuated the severe fibrotic response of the mouse lung induced by 3.2 U/kg bleomycin given intratracheally (Oury et al. 2001). 

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