Bispyridinium dicarbaldoximes

Kuca et al (2004a) also synthesized and in vitro tested activity of symmetric bispyridinium dicarbaldoximes against cyclosarin-inhibited AChE (Figure 66.25). 

Kuca et al. (2004a) also synthesized and tested activity of symmetrical bispyridinium dicarbaldoximes (4-5 Figure 72.6) in vitro against cyclosarin-inhibited AChE. The compound l,4-bis(2-hydroxyiminomethylpyridin-ium)butane dibromide (4 K033) gave promising results in in vitro reactivation of cyclosarin-inhibited AChE compared to commonly used pralidoxime. 

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