Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Bisphosphonates peptide prodrugs

The oral absorption of an entirely different class of drugs, namely bisphosphonates, has also been improved by a peptide prodrug strategy [36]. The drugs pamidronate (6.13, n=2) and alendronate (6.13, n=3) were deriv-atized with the Pro-Phe-dipeptidyl unit to yield the prodrugs Pro-Phe-pamidronate (6.14, n=2) and Pro-Phe-alendronate (6.14, n=3), the ob-... [Pg.268]

A. Ezra, A. Hoffman, E. Breuer, I. S. Alferiev, J. Monkkonen, N. El Hanany-Rozen, G. Weiss, D. Stepensky, I. Gati, H. Cohen, S. Tormalehto, G. L. Amidon, G. Golomb, A Peptide Prodrug Approach for Improving Bisphosphonate Oral Absorption , J. Med. Chem. 2000, 43, 3641-3652. [Pg.370]

Bisphosphonates pamidronate and alendronate (the most active bisphos-phonates approved for clinical use) were converted into the peptidyl prodrugs prolyl-phenylalanylpamidronate [Pro-Phe-pamidonate (420)] and prolyl-phenylalanyl-alendronate [Pro-Phe-alendronate (421)]. It was shown that the bioavailability of bisphosphonates can be enhanced by using the peptide prodrug approach. The increased oral absorption of the prodrugs was reduced by an active carrier-mediated transport. ... [Pg.181]

Ezra, A. Hoffman, A. Breuer, E. Alferiev, I.S. Monkko-nen, J. ElHanany-Rozen, N. Weiss, G. Stepensky, D. Gati, I. Cohen, H. Tormalehto, S. Amidon, G.L. Golomb, G. A peptide prodrug approach for improving bisphosphonate oral absorption. J. Med. Chem. 2000, 43, 3641-3652. [Pg.1860]


See other pages where Bisphosphonates peptide prodrugs is mentioned: [Pg.269]    [Pg.292]   
See also in sourсe #XX -- [ Pg.251 , Pg.252 ]




SEARCH



Bisphosphonate

Bisphosphonates

Bisphosphonates prodrugs

Prodrug

© 2024 chempedia.info