Bisoprolol Theophylline

Warrington SJ, Johnston A, Lewis Y, Murphy M Bisoprolol studies of potential interactions with theophylline and warfarin in healdiy volunteers. J Cardiovasc Pharmacol (1990) 16 (Suppl 5), S164-S168. 

Propranolol reduces the clearance of theophylline. More importantly, non-cardioselective beta blockers such as nadolol and propranolol, should not be given to asthmatic patients because they can cause bronchospasm. The concurrent use of theophylline and cardioselective beta blockers such as atenolol, bisoprolol or meto-prolol is not contraindicated, but some caution is still appropriate. Atenolol and bisoprolol do not affect the pharmacokinetics of theophylline. 

A study in 8 healthy subjects (5 of whom smoked 10 to 30 cigarettes daily) found that the clearance of a single 5.7 to 6.4 mg/kg dose of theophylline (as intravenous aminophylline) was reduced by 37% by propranolol 40 mg every 6 hours, when compared with theophylline alone. Metopro-lol 50 mg every 6 hours did not alter the clearance in the group as a whole, but the smokers had an 11% reduction in clearance. Another study, in 7 healthy subjects, found that the steady-state plasma clearance of theophylline was reduced by 30% by propranolol 40 mg every 8 hours, and by 52% by propranolol 240 mg every 8 hours. However, a further study found no significant pharmacokinetic interaction between theophylline and propranolol. Three other studies found that the cardioselective beta blockers atenolol 50 to 150 mg, - and bisoprolol 10 mg, and the non-se-... 

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