Rifampicin Bisoprolol

BETA-BLOCKERS RIFAMPICIN L plasma concentrations and efficacy of bisoprolol, carvedilol, celiprolol, metoprolol and propanolol Rifampicin induces hepatic enzymes (e.g. CYP2C19), which t metabolism of the beta-blockers in addition, it may also t P-gp expression Monitor PR and BP watch for poor response to beta-blockers... 

Kirch W, Rose I, Klingmannl, Pabst J, Ohnhaus EE. Interaction of bisoprolol with cimetidine and rifampicin. EurJCUn Pharmacol (1986) 31, 59-62. 

Rifampicin increases the clearance of bisoprolol, carvedilol, celiprolol, metoproioi, propranolol, tertatolol and talinolol, and reduces their serum levels. The extent to which this reduces the effects of these beta blockers is uncertain, but it is probably small. Similar effects have been seen when atenolol is given with rifampicin, but a case report su ests that occasional the effects may be of clinical relevance. 

The AUC of bisoprolol 10 mg daily was reduced by 34% in healthy subjects given rifampicin 600 mg daily... 

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See also in sourсe #XX -- [ ]

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