Bisnaphthyridines

Analogous condensation 203 with dione 217 in ethanol in the presence of piperidine base afforded a mixture of polyannulated bisnaphthyridines 218-220 in a total yield of 82% (1992JCS(P1)1747). 

New bisnaphthyridines 352 and 353 containing the 5-amino-2,4-dime-thylbenzo[Z>][l,8]naphthyridine or benzo[Z>][l,8]naphthyridone chromophores were synthesized in a phase-transfer system by the reaction of aminobenzonaphthyridine 354 or dihydrobenzonaphthyridone 355 with alkylene dibromides (2000JHC1289). Such bisintercalates are of interest as potential antitumor drugs. 

---

See also in sourсe #XX -- [ ]

---