Biscarboxychromonyloxy propanol ointment

The disodium salt of l,3-bis(2-carboxychromon-5-yloxy) propan-2-ol is added slowly in small portions, with vigorous mixing, to a small portion of the preheated and sterilized components of the ointment base at 90°C. 

When the addition is complete, mixing is continued for a further 15 minutes, and then the concentrated dispersion is sterilized by heating at 150°C for 1 hour. 

The concentrated dispersion is then added to a homogenizer heated at 80°-100°C, and the remaining components of the ointment basis are added slowly with continuous blending. 

When this addition is complete, the molten ointment is blended for a further 15 minutes and then cooled to a temperature of 58°-62°C. 

The ointment is then filled in presterilized eye ointment tubes, which are crimped and allowed to cool to room temperature. 

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