Bis 2-phenylethyl

IV-acetyl pyrrolidines and -piperidines to the corresponding diones or ketones were similarly effected [405, 406], as were conversions of diacetyl and dibenzyl piperazines to diketo componnds by the same system (Table 5.1) [407]. Methylene groups adjacent to the N atom in tertiary polycyclic amines were oxidised by RuO /aq. NaCIO j/CCl (Fig. 5.5) [408]. A large-scale oxidation of l,4-bis(2-phenylethyl) piperazine to the dione was made by RnO /aq. Na(10 )/Et0Ac [409], and RuO /aq. Na(IO )/CCl converted dialkyl or diaryl A A -dimethyladenosines to the corresponding monoamido derivatives (Fig. 5.4) [410]. 

The dibenzazonine (13), related to a biosynthetic precursor of the Erythrina alkaloids, has been prepared in 35% yield by the intramolecular nickel-promoted coupling of the bis-(2-phenylethyl)amine (14), which in turn was obtained from the commercially available (3-methoxyphenyl)acetic acid by a conventional series of reactions.16... 

The two center structures show the complex that forms between iV,iV -bis(2-phenylethyl)-4,13-diaza-18-crown-6 and KI <2000PNAS6271>. The K+ ion is bound in the center of the macroring, as expected for any 18-crown-6 macrocycle. The twin sidearms of the bibracchial lariat ether turn inward in this complex and the arenes serve as apical donors. The top center structure shows the symmetrically bound cation and illustrates that the iodide anion is excluded from the cation s solvation sphere. The bottom center structure shows the superimposition of the two benzene rings upon each other and upon the K+ ion. Note in the bottom center structure that the iodide anion is not illustrated. The ideal sandwich of arene-cation-arene confirms the cation-pi interaction between benzene and K+. 

Mizuguchi, J. (1998a). Electronic characterization of N, A -bis(2-phenylethyl)peryl-ene-3,4 9,10-bis(dicarboximide) and its application to optical disks. J. Appl. Phys., 84, 4479-85. [264, 265Q... 

The amides are obtained in good yields starting from (un)-substituted benzonitriles. For example with the terephtalonitrile the interesting diamide N,N -bis (2-phenylethyl)terephtalamide is obtained in good conditions (an extension of this reaction starting from diamines could lead to the formation of polyamides). However, the same reaction performed with adiponitrile, affords mainly the monoamide as the monoaminolysis product. 

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