Biotinylated interface design

Our motivation for mixing PLL-g-PEG and PLL-g-PEG/ PEGbiotin was to tailor the chip surface in terms of specific analyte—surface interactions and to reduce or eliminate nonspecific adsorption. On the mixed polymeric interfaces, biotin sites from PLL-g-PEG/PEGbiotin were designed for the specific adhesion of proteins, such as streptavidin or avidin, which can specifically bind further biotinylated moieties (e.g., oRIgG biotin), which in turn can capture... 

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