Biosynthetic processes chemical challenges

Anthracyclines are large and chemically labile molecules, which makes their synthetic modification challenging, hi biosynthetic methods, reactions are performed mostly in neutral aqueous solutions at moderate temperatures. Enzymatic reactions are highly specific for the position as well as the stereoisomer modified Hkewise, chiral products are exclusively of one stereoisomer. Particularly in vivo, in Hving organisms, enzymatic reactions can be combined to perform several modifications in one process, or, indeed, to build the entire molecule from simple precursors. One of the strengths of biosynthetic methods is also their main weakness only modifications for which an enzyme exists can be performed. 

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