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Biosynthesis of Thyroglobulin

Fig. 34.2. Summary of the major pathways for the biosynthesis and secretion of the thyroid hormones. When thyrotropin (TSH) binds to the TSH receptor at the basal membrane of the follicular cell, the biosynthesis of thyroglobulin (TG) is stimulated, as is that of thyroperoxidase (TPO) and the production of hydrogen peroxide. Noniodinated TG is synthesized by the rough endoplasmic reticulum of the follicular cell and secreted through the apical membrane of the follicular cell into the follicular lumen. Iodide enters the follicular cell by the iodide pump (NIS, sodium iodide symporter) and is then transported into the follicular lumen. In the lumen, the iodide is oxidized by TPO-O (a Ti-cation radical intermediate formed from TPO and hydrogen peroxide) at the apical... Fig. 34.2. Summary of the major pathways for the biosynthesis and secretion of the thyroid hormones. When thyrotropin (TSH) binds to the TSH receptor at the basal membrane of the follicular cell, the biosynthesis of thyroglobulin (TG) is stimulated, as is that of thyroperoxidase (TPO) and the production of hydrogen peroxide. Noniodinated TG is synthesized by the rough endoplasmic reticulum of the follicular cell and secreted through the apical membrane of the follicular cell into the follicular lumen. Iodide enters the follicular cell by the iodide pump (NIS, sodium iodide symporter) and is then transported into the follicular lumen. In the lumen, the iodide is oxidized by TPO-O (a Ti-cation radical intermediate formed from TPO and hydrogen peroxide) at the apical...
In conclusion, the biosynthesis of thyroglobulin appears to foUow the same pattern as described above for liver (Section IV,A). Sugars are... [Pg.73]

See other pages where Biosynthesis of Thyroglobulin is mentioned: [Pg.112]    [Pg.534]   


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Thyroglobulin

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