Biopolymer mimetics

Azatide oligomers are biopolymer mimetics consisting of a-aza-amino acids linked in a repetitive manner. The molecular structures of azatide and azapeptide fragments are compared in Figure 7.18. 

Using the solid-phase strategy also libraries of other biopolymer mimetics have become accessible, for example, oligoureas, oligo-sulfones, peptidosulfonamides, [14] peptido-phosphoramidates, and peptoids (Scheme 2). 

P. Gillespie, J. Cicariello, G.L. Olson, Conformational analysis of dipeptide mimetics. Biopolymers 43 (1997) 191-217. 

Burke TRJ, Yao Z-J, Liu D-G, Voigt J, Gao Y. Phosphoryltyro-syl mimetics in the design of peptide-based signal transduction inhibitors. Biopolymers 2001 60 32-44. 

Guarracino DA, Bullock BN, Arora PS (2011) Protein-protein interactions in transcription a fertile ground for helix mimetics. Biopolymers 95 1-7... 

Gibson G, El-Agnaf OM, Anwar Z, Sidera C, Isbister A, Austen BM (2005) Stmcture and neurotoxicity of novel amyloids derived from the BRI gene. Biochem Soc Trans 33 1111-1112 Gillespie P, Cicariello J, Olson GL (1997) Conformational analysis of dipeptide mimetics. Biopolymers 43 191-217... 

M. Chorev, E. Roubini, C. Gilon, and Z. Selinger, Biopolymers, 31, 725 (1991). Toward Nonpeptidal Substance P Mimetic Analogues Design, Synthesis, and Biological Activity. 

Dendrimers have also found application as carriers of genetic materials into cells [84,298-300]. In this usage, the dendrimers can be thought of as a histone mimetic. With appropriately charged surface groups the polycationic dendrimers forms a supramacromoleeular complex with the poly-anionie nucleic acid biopolymer. This dendrimerie nanodevice transports the genetic material across... 

---