Biomolecules inflammatory mediators

Surface properties of an implantable device are of critical importance since the first contact with the organism is mediated by the interface. This interaction is what drives the subsequent tissue and cellular events, including protein adsorption, cell adhesion, and inflammatory response (Castner and Ratner, 2002 Cole et ai, 2009 Stevens and George, 2005). Thus, instructive biointerfaces will first dictate the type of cell that attach and instruct the cell behavior through the motifs presented. Scaffold materials can be functionalized with bioactive molecules, to influence cell adhesion and regulate cell function, either by physical adsorption of specific biomolecules or by chemical immobilization. 

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