Biomimetic Transformations of Polyunsaturated Fatty Acids

PUFAs can be used in their own right as starting material for the semisynthesis of more complex members of the PUFA family. A particular advantage using this approach is the conservation of the methylene-interrupted double bonds throughout the synthesis and to be present in the final product. 

Corey and coworkers devised a highly selective internal epoxidation of arachidonic acid (8) to afford epoxy methyl 

SCHEME 3.26 Synthesis of the four metahohtes 96-99 of arachidonic acid (8) [77]. 

SCHEME 3.28 Kuklev and coworkers synthesis of all-cw-3,6,9,12,15-octadecapentaenoic acid (107) [82]. 

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