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Biomimetic siderophores ferrichromes

The closely related structures show completely different microbial uptake characteristics. The 3D structures described above show distinct different orientation of the backbone amide (tangental in type 1 versus radial in type 2), which can be explained by the interactions that take place between the FhuA receptor and the ferrichrome siderophore -As mentioned, the second coordination sphere of natural ferrichrome in FhuA receptor is very sensitive to the distance and orientation between a proton donor and the proton acceptor, therefore the orientation of the amide groups in the biomimetic siderophore plays a crucial role in receptor recognition. [Pg.776]

The second group of hydroxamate-based chelators consists of biomimetic ferrichrome analogs modified by introducing hydrophobic amino acids between the template and the hydroxamic acid binding sites 59, 60, 66, 68, 70, 199 and 200. Since they function to withhold iron from cells in contrast to their original function of iron delivery, they were named reversed siderophores (RSF) . ... [Pg.805]

See other pages where Biomimetic siderophores ferrichromes is mentioned: [Pg.755]    [Pg.755]    [Pg.769]    [Pg.142]    [Pg.760]    [Pg.795]    [Pg.558]    [Pg.35]   
See also in sourсe #XX -- [ Pg.763 , Pg.764 , Pg.765 , Pg.766 , Pg.767 , Pg.768 , Pg.769 , Pg.770 , Pg.771 , Pg.772 , Pg.773 , Pg.774 , Pg.775 , Pg.776 , Pg.777 , Pg.778 , Pg.779 , Pg.795 , Pg.805 , Pg.806 ]



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