Biomime tic

In 1999, Yamamoto reported the first example of an enantioselective biomime tic polyene cychzation using chiral LBAs as artificial cyclases. The LBA cyclase is believed to participate in the initial enantioselective protonation of the terminal isoprenyl group which induces concomitant diastereoselective cychzation [128]. Subsequent work by the Yamamoto group led to the development of LBA 52 as an artificial cyclase for hydroxypolyprenoids (Scheme 5.68) [129]. LBA 52 mediated cychzation of the the appropriate achiral hydroxypolypreniods permitting the short total syntheses of (-)-Chromazonarol, (-i-)-8-epi-puupehedione, and (-)-ll -deox-ytaondiol (not shown). 

Biomime tic electrochemical sensors based on molecular imprinting... 

Biomime tic Electron-transfer Chemistry of Porphyrins and Metalloporphyrins... 

Gellerman et al. (94T12959) have described the biomime tic synthesis of a pyrrolo[2,3,4-k/]acridine 305 (Scheme 57). 

Figure 6 Model (a) and structure (b) of a T1, T2 coupled biomime tic. The E° values reflected the ligand field differences at the two Cu intramolecular electron transfer was not demonstrated ...

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