Biomarkers cytochrome P450 induction

Several PAHs and hydroxylated or methylated PAH derivatives induce oestrogenic or dioxin-like (antioestrogenic) effects in fish and mammalian cell lines (Santodonato, 1997 Villeneuve et al., 2002 Michallet-Ferrier et al., 2004). For instance, benz[u]anthracene and dibenz[u/2]anthracene elicit oestrogenic responses in vitro (Villeneuve et al., 2002). These two PAHs and five others may also elicit dioxin-like responses, as shown by their induction of ethoxyresorufm-D-deethylase (EROD) activity, a biomarker for cytochrome P450 lAl (Gravato Santos, 2002 Villeneuve et al., 2002). 

Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini. Cancer Epidemiol. Biomarkers Prev. 5, 795—800. 

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