Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Biomarkers bone lead levels

Lead is believed to directly incorporate into the calcium sites in hydroxyapatite in bone. Bone lead levels provide a useful biomarker of long term, cumulative exposure to lead, because the half-life of lead in bone is >10 years... [Pg.118]

Reduction in the serum 1,25-dihydroxyvitamin D concentration has been reported as an indicator of increased lead absorption or lead levels in the blood (Rosen et al. 1980). Lead inhibits the formation of this active metabolite of vitamin D, which occurs in bone mineral metabolism (EPA 1986a Landrigan 1989). Children with PbB concentrations of 12-120 pg/dL lead showed decreased serum 1,25-dihydroxyvitamin D concentrations comparable to those found in patients with hypoparathyroidism, uremia, and metabolic bone disease (Mahaffey et al. 1982 Rosen et al. 1980). This biomarker is clearly not specific for lead exposure and several diseases can influence this measurement. [Pg.316]

See other pages where Biomarkers bone lead levels is mentioned: [Pg.310]    [Pg.317]    [Pg.318]    [Pg.351]    [Pg.355]    [Pg.312]    [Pg.316]    [Pg.458]    [Pg.286]    [Pg.472]    [Pg.347]    [Pg.56]    [Pg.56]    [Pg.65]    [Pg.2405]    [Pg.293]    [Pg.511]    [Pg.577]    [Pg.728]   
See also in sourсe #XX -- [ Pg.118 ]



SEARCH



Bone, lead

Lead levels

© 2024 chempedia.info