Biomacromolecular binding

Most biomacromolecular interactions (bindings) involve the formation of some types of noncovalent bond and some specific region of the macromolecule called the binding site. Determinations of equilibrium binding processes are mostly indirect in that either i) the fraction of all of the ligand molecules (generally labeled molecules are used) in the system that are bound or ii) the fraction of binding sites that are occupied, is measured. 

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