Bioluminescence Gonyaulax polyedra

Bode, V. C., and Hastings, J. W. (1963). The purification and properties of the bioluminescent system in Gonyaulax polyedra. Arch. Biochem. Biophys. 103 488-499. 

Dunlap, J. C. (1979). Circadian organization of bioluminescence in Gonyaulax polyedra. Ph.D. Dissertation, Harvard University, Cambridge, MA. 

Morse, D., Fritz, L., Pappenheimer, A. M., Jr., and Hastings, J. W. (1989). Properties and cellular localization of luciferin binding protein in the bioluminescence reaction of Gonyaulax polyedra. J. Biolumin. Chemi-lumin. 3 79-83. 

Fig. 11.2. Circadian rhythm of bioluminescence in Gonyaulax polyedra (Taylor et al., 1989b). The curves in (a) show phase-shifts of the rhythm by pulses of anisomycin, an inhibitor of protein synthesis. The concentration of anisomycin used is indicated along the vertical axis, as well as the time at which the drug is administered. Experiments shown indicate phase-shifts produced by 1 h pulses of 0.1 pM (vials 2 and 20) and 0.2 pM (vials 3 and 21) anisomycin. Vertical lines indicate positions of control peaks (vials 7 and 25). Drug pulses given between hours 11 and 12 (vials 2 and 3) resulted in phase delays as compared to control (vial 7) pulses given from hours 14 to 15 resulted in phase advances compared to control (vial 25). (b) A phase response curve for 1 h pulses of 0.3 pM anisomycin. Conditions are as in (a). Time on the abscissa denotes beginning of the pulses, in hours since cells were transferred to constant conditions. A positive phase shift denotes a phase advance.

Nakamura, H., Ohtoshi, M., Sampei, O., Akashi, Y, and Murai, A. (1992) Synthesis and absolute configuration of (+)-gonyauhne a modulating substance of bioluminescent circadian rhythm in the unicellular alga Gonyaulax polyedra. Tetrahedron Lett., 33, 2821-2822. 

---