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Biologies critical decision making

Pharmaceuticals are intended to have human exposure. Furthermore, pharmaceuticals are intended to have biological effects on the people that receive them. Frequently, the interpretation of results and the formulation of decisions about the continued development and eventual use of a drug are based on an understanding of both the potential adverse effects of the agent and its likely benefits, as well as the dose separation between these two. This makes a clear understanding of dose-response relationship critical, so that the actual risk/benefit ratio can be identified. It... [Pg.638]

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