Biological Studies on Platinum—Pyrimidine Blue Precursors

Biological Studies on Platinum—Pyrimidine Blue Precursors 

The many pyrimidine complexes synthesized and structurally characterized in the foregoing work will clearly be of great use in elucidating the full potential of the biological activity of these complexes. The suggestion has been made that the activity reported could be due to slow release, by hydrolysis, of dimers and monomers [69]. Initial studies on some of these 

The binding to DNA of the precursor complexes must also be considered. An early report of selective tumour cell surface staining was of considerable interest [65] but was not confirmed [71] and must be considered erroneous. Initial studies on DNA binding have also been reported [71]. 

Lippert Platinum(II) Complex Formation with Uracil and Thymine (Platinum, Gold, and Other Metal Chemotherapeutic Agents, ACS Symposium Series 209, Ed. S. J. Lippard), p. 147. ACS Washington (1983). 

Schollhorn, U. Thewalt, and B. Lippert Inorg. Chim. Acta 106,177 (1985). 

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Biological Studies on Platinum—Pyrimidine Blue Precursors... 

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