Biological space scaffolds

Figure 1 Representation of some of the interfaces between biology and chemistry space (a) the continuum of chemistry space continuum with representative regions of specific biological activity highlighted (b) large combinatorial libraries seek to cover as much space as possible across several biological families but with one core scaffold (c) smaller focused libraries, shown as the small blue cubes, are designed with relevant biological targets in mind and(d) libraries that do not overlap with relevant biological space are undesirable...

Novel access to diverse backbones is of crucial interest for several areas of organic chemistry. For example, a novel, previously undescribed scaffold with biological activity provides a patent-free chemical space. Moreover, if this scaffold is accessible by MCR chemistry this has several advantages of resource and time saving. Often more variations around the principal scheme are possible. 

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