Biological Properties of Prostanoids

Catabolism of PGE2 and PGF2 , 15-PGDH = 15-Hydroxy-PG-dehydrogenase I3-PGR= 13-PG-reductase. 

Leukotrienes (LTs) are most commonly found in leukocytes, mast cells, platelets, and vascular tissues of the lung and heart. They are formed chiefly from arachidonic acid. 

Structures of leukotriene receptor antagonists, (a) Zafirlukast and (b) montelukast. 

Ascherio, M. B. Katan, P. L. Zook, et al. Trans fatty acids and coronary heart disease. New England Journal of Medicine 340, 1994 (1999). 

Blitzer, et al. Retrospective biochemical screening of fatty acid oxidation disorders in postmortem livers of 418 cases of sudden death in the first year of life. Journal of Pediatrics 132, 924(1998). 

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