Biological phosphorylating agents

Figure 13-3. Structures of the most important biological phosphorylating agents. P = phosphate.

The biological properties of a phosphorothiolate S -oxide presumably depend in part on the relative rate at which it reacts as a phosphorylating agent as opposed to the rate it rearranges to the phosphinyloxysulfenate (Eq. 3). A simple experiment... 

In the search for biologically active compounds a method was proposed [143] for the synthesis of phosphorus-containing hydrazones of 3-formylindole 147. Here hydrazides of diphenylphosphorylcarboxylic acids, which possess high biological activity [144], were used as phosphorylating agents. 

Mechanistic features of phosphoryl transfer and methods of investigation. The chemical phosphorylation of carbohydrates is of importance only in the synthesis of phosphorylated carbohydrates of biological importance. Common phosphorylating agents for monophosphates are dibenzyl or diaryl phosphorochloridates, ClPO(OAr)2 and ClPO(OBn)2 benzyl groups can be removed by catalytic hydrogenation. 

Phosphorylations with low-potential phosphorylating agents are thermodynamically not favorable. In biological systems, these processes are made possible by... 

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